![]() ![]() These results deepen the understanding of the evolution and function of IDDs. In sum, intrinsic domain disorder is related to both the organism complexity and clade-specific functions. Some clade-specific ‘no-variation’ or ‘high-variation’ domains are involved in clade-specific functions. As for disorder variation, it’s greater for domains among different proteins than those within the same proteins. Compared with metazoans, fungi have more IDDs with a consecutive disorder region but a low disorder ratio, which reflects their different functional requirements. The functions of IDDs are clade-specific and the higher proportion of post-translational modification sites may contribute to their complex functions. These phenomena may be due to the high disorder of clade-specific domains and the different disorder degrees of the domains shared in different clades. As the result, there is a significant positive correlation between the proportion of IDDs and organism complexity with some interesting exceptions. Here, we address these issues by genome-wide analyses of the evolutionary and functional features of IDDs in 1,870 species across the three superkingdoms. However, the evolutionary causes and biological significance of these phenomena are unclear. Interestingly, some protein domains are intrinsically disordered (abbreviated as IDD), and the disorder degree of same domains may differ in different contexts. ![]()
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